what will happen to the urine volume if adh is not added to the collecting duct? This is a topic that many people are looking for. amritsang.org is a channel providing useful information about learning, life, digital marketing and online courses …. it will help you have an overview and solid multi-faceted knowledge . Today, amritsang.org would like to introduce to you Water Regulation by Antidiuretic Hormone (ADH). Following along are instructions in the video below:
Guys welcome to my channel today im going to discuss about water regulation by by antidiuretic hormone. Which is also called vasopressin lets see where the adh comes here. This is hypothalamus and just beneath the hypothalamus.
There is pituitary gland. There are lots of nucleus present in the hypothalamus. One of such important nucleus is supraoptic nucleus this nucleus synthesized adh.
Which comes down to the pituitary gland here. I would like to mention an important concept. That adh synthesized in hypothalamus and secrete from the posterior pituitary.
So posterior pituitary. Doesnt produce adh. It is just like a storehouse from where a dea secrets into the general circulation now adh is anti derivative hormone.
Which means it doesnt allow diuresis or water loss. So it is water conserving hormone.
Now what circumstances you need to conserve water well. When your blood or extracellular water is hyperosmolar. Suppose you were working alone in a desert without drinking water and food so you are continuously losing water through sweating perspiration and urination which will eventually make your blood and extracellular fluid hyperosmolar.
So in this situation your blood need to conserve water here adh comes into action. It helps the body to reabsorb water from the crede knee as we know normal australia of the blood is 290 to 300 million per litter so if your bodys deprived of water and blood osmolarity goes up more and more adh old secrete to keep the australia around the normal value. Lets see how this whole system works.
You must be knowing about osmo receptors. Here. This is hypothalamus and this is third ventricle.
Internal lateral area of third ventricle having some osmo receptors. Which can sense osmolarity of the blood two such specialized structures are suffer nickel organ and organm hast callosum is part of central nervous system doesnt have an intact blood brain barrier. So blood or blood products can easily come in contact with the specialized structures.
So that they can sense the osmolarity of the blood and give signal to the hypothalamus for a da secretion. Now lets see how adh works here.
I would like to give you another important information. As you know the other name of adh is recip resin because it can cause vasoconstriction. But to produce anti diuresis small amount of adh is enough whether for vasoconstriction it needs more amount of or larger amount of adh so in low concentration.
It acts as an antidiuretic hormone and in high concentration. It acts as a vasoconstrictor by the time. A luminal fluid reaches to the distal part of the nephron precisely late part of distal.
Convoluted tubule and collecting duct area. It is highly diluted the osmolarity around 50 200 million small palate now this is important to know that the water permeability of the last part of the nephron is adh dependent. If adh is not there it will remain water impermeable.
It means no water can reserve back to the general circulation. So it will pass out as earrin now. Lets see how adh alter the cellular environment.
Since of this part of nephron have receptor for adh there serpentine receptor. All seven pass receptor adh binds with this serpentine receptor.
Which is stimulate intercellular g protein. And intercellular g protein. Stimulates adenylyl cyclase.
Which convert atp into cyclic amp. When intracellular cyclic amp e goes up it will phosphorylate protein kinase. A all these steps are nothing.
But to activate this enzyme. Now you can see there are some intracellular vesicles. Those vesicles are having some special protein channels.
Which look like pores and water can pass through it. Thats why those protein channels are called aquaporins. Now protein kinase.
A phosphorylates those proteins and they get fused with the luminal membrane of the nephron. Another important concept here you can see the collecting duct lumen.
So this side of the cell is luminance. Id and opposite side is visual lateral side actually there are different types of echo pouring channels channels. Which are present on the basolateral side and luminal cells are different only luminal side.
Echo pouring channels are regulated by adh so in the presence of adh echo. Pouring channels are planted on the luminal side of the nephron. So adh makes this portion water permeable.
Now listen carefully the interest trishal fluid. Here is hyper or smaller. But the luminal fluid is hypo smaller.
So the direction of the water will be from here to here. Which means water reserve back to the interstitial fluid from luminal fluid in the presence of adh. So.
If adh is present distal part of the nephron will be water permeable and you will pass concentrated urine. But if adh is not there extra water will come out of your body as diluted urine. Thats all guys.
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